منابع مشابه
MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus.
Subjects with type 1 diabetes mellitus (T1DM) have decreased bone mineral density and an up to sixfold increase in fracture risk. Yet bone fragility is not commonly regarded as another unique complication of diabetes. Both animals with experimentally induced insulin deficiency syndromes and patients with T1DM have impaired osteoblastic bone formation, with or without increased bone resorption. ...
متن کاملDiabetes Mellitus
دیابت بیماری متابولیکی است که بدلیل افزایش سطح گلوکز خون (هیپرگلیسمی) بدنبال بروز معایبی در ترشح انسولین، عملکرد انسولین یا هر دو عامل بروز می نماید.
متن کاملAGEs and Bone Ageing in Diabetes Mellitus
Type 1 and type 2 Diabetes mellitus are associated with a decrease in bone quality that leads to an increase in low-stress fractures, a condition called diabetic osteopathy. A growing body of evidence strongly indicates that one of the main pathological mechanisms of diabetic osteopathy is an excess accumulation of advanced glycation end products (AGEs) on collagen of bone extracellular matrix....
متن کاملBone mass in Type 1 diabetes mellitus
Several recent studies suggest that diabetes mellitus is an underlying disease for secondary osteoporosis. Furthermore, the risk of fracture is increased in diabetic patients irrespective of their diabetic clinical type. The objective of this is study was to evaluate the bone mineral mass of children with Type 1 Diabetes Mellitus and compare them according to time of diagnosis, to observe the i...
متن کاملDiabetes mellitus induces bone marrow microangiopathy.
OBJECTIVE The impact of diabetes on the bone marrow (BM) microenvironment was not adequately explored. We investigated whether diabetes induces microvascular remodeling with negative consequence for BM homeostasis. METHODS AND RESULTS We found profound structural alterations in BM from mice with type 1 diabetes with depletion of the hematopoietic component and fatty degeneration. Blood flow (...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 2018
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.0905-18